Lincoln Six-Echo (McGregor) is a resident of a seemingly utopian but contained facility in the mid-21st century. Like all of the inhabitants of this carefully controlled environment, Lincoln hopes to be chosen to go to the "The Island" - reportedly the last uncontaminated spot on the planet. But Lincoln soon discovers that everything about his existence is a lie. He and all of the other inhabitants of the facility are actually human clones whose only purpose is to provide "spare parts" for their original human counterparts. Realizing it is only a matter of time before he is "harvested", Lincoln makes a daring escape with a beautiful fellow resident named Jordan Two-Delta (Johansson). Relentlessly pursued by the forces of the sinister institute that once housed them, Lincoln and Jordan engage in a race for their lives to literally meet their makers.